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. 2021 Jun 12;7:401–411. doi: 10.1016/j.bioactmat.2021.05.042

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Application principle and mechanical property of the ALG-HA hydrogels. (a) Schematic of the preparation process of the composite hydrogel and MI therapy. (i) The composition of hydrogel: ALG and HA; (ii) The preparation of Ly-PRF: venipuncture, centrifuge and lyophilize for 12 h; (iii) Mechanical support for weak ventricular wall; (iv) Inducing infiltration of microvasculature in both IZ and BZ. (b) Fabrication of Ly-PRF via lyophilization. (c) The macrophotographs of ALG-HA hydrogels with PRP or Ly-PRF. (d) Dynamic rheology curves for the ALG-HA hydrogels with PRP or Ly-PRF. ALG, alginate; HA, hyaluronic acid; PRP, platelet rich plasma; Ly-PRF, lyophilized platelet-rich fibrin; IZ, infarcted zone; BZ, border zone.