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. 2021 Jun 12;7:401–411. doi: 10.1016/j.bioactmat.2021.05.042

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Microstructure and drug delivery ability of the ALG-HA hydrogels. (a) SEM images of ALG-HA hydrogels with PRP or Ly-PRF. (b, c) The representative images (b) and the swelling ratio (c) of ALG-HA hydrogels with PRP or Ly-PRF; n = 5 per group. (d) Tube formation assay for all groups. (e, f) Quantitative analysis of nodes (e) and tube length (f); n = 5 per group. (g) The cumulative release of PDGF-AA from ALG-HA hydrogels with PRP or Ly-PRF; n = 5 per group. The data in (e, f) are expressed as mean ± standard deviation and analyzed using One-way ANOVA followed by Bonferroni post hoc test. ***p < 0.001 compared with PBS group; ^†††p < 0.001 compared with ALG-HA group; ^‡‡‡p < 0.001 and ^‡‡p < 0.01 compared with ALG-HA (PRP) group. ALG, alginate; HA, hyaluronic acid; PRP, platelet rich plasma; Ly-PRF, lyophilized platelet-rich fibrin.