Fig. 6.

TOs delivery based on the DNA/RNA nanoassembly. (a) Self-assembled DNA tetrahedral nanostructure for targeted siRNA delivery (arrow head represents 5 end of the nucleic acid strand). Reproduced according to Ref. [301].; (b) Stepwise self-assembly of D-PGM for three-receptor-mediated cell identification and targeted cancer therapy. Reproduced with permission [305], Copyright 2020, American Chemical Society; (c) Self-assembly of CpG-bearing DNA tetrahedrons and their multivalent immunostimulatory effect evaluations. Reproduced with permission [306], Copyright 2011, American Chemical Society. (d) Nucleic acid nanoparticles (NANPs) differing in size, shape, composition, connectivity, and sequence complementarity for immunological recognition investigations. Reproduced with permission [312], Copyright 2018, American Chemical Society.