Fig. 3.

The top 20 most common prioritized phenotypes for Juul aerosol chemicals associated with pulmonary fibrosis, asthma and lung neoplasms. CGPD-tetramers were computationally generated for four chemicals in Juul aerosols (nicotine, formaldehyde, acetaldehyde, and particulate matter), interacting genes, intermediate phenotypes, and three respiratory tract diseases (pulmonary fibrosis, asthma and lung neoplasms). A total of 65 phenotypes were prioritized as shared among the CGPD-tetramers for the three target respiratory diseases, and annotated to the specific chemicals, genes in the inference network, and respiratory system, and the 20 most frequent phenotypes are presented as number of CGPD-tetramers per phenotype for each disease.