Table 4.
Multivariate Analyses of Factors Associated with Overall Survival (OS) and Cancer-Specific Survival (CSS) in the Training Group
| Characteristics | Overall Survival | Cancer-Specific Survival | ||
|---|---|---|---|---|
| Hazard Ratio (95% CI) | P value | Hazard Ratio (95% CI) | P value | |
| Age, y | ||||
| ≤65 | Reference | Reference | ||
| >65 | - | 0.657 | 0.402 | |
| Gender | ||||
| Male | Reference | Reference | ||
| Female | 2.25 (1.14–4.44) | 0.020 | 0.284 | |
| BMI, kg/m2 | ||||
| <25 | Reference | Reference | ||
| ≥25 | - | 0.457 | 0.497 | |
| Hypertension | ||||
| No | Reference | Reference | ||
| Yes | - | 0.484 | 2.95 (1.33–6.54) | 0.008 |
| Diabetes | ||||
| No | Reference | Reference | ||
| Yes | - | 0.561 | - | 0.789 |
| Cardiovascular Diseases | ||||
| No | Reference | Reference | ||
| Yes | - | 0.577 | - | 0.633 |
| Smoking | ||||
| No | Reference | Reference | ||
| Yes | - | 0.881 | - | 0.847 |
| Surgery Type | ||||
| Partial nephrectomy | Reference | Reference | ||
| Radical nephrectomy | - | 0.183 | 4.65 (1.51–14.28) | 0.007 |
| Laterality | ||||
| Left | Reference | Reference | ||
| Right | - | 0.889 | - | 0.828 |
| AJCC stage | ||||
| I | Reference | Reference | ||
| II | - | 0.290 | 1.13 (0.11–6.88) | 0.583 |
| III | - | 0.203 | 2.10 (0.68–6.46) | 0.196 |
| IV | - | 0.077 | 11.53 (4.62–28.75) | <0.001 |
| T-stage | ||||
| T1 | Reference | Reference | ||
| T2 | - | 0.794 | - | 0.033 |
| T3 | - | 0.297 | - | 0.491 |
| T4 | - | 0.162 | - | 0.310 |
| N-stage | ||||
| N0 | Reference | Reference | ||
| N1 | - | 0.056 | - | 0.254 |
| M-stage | ||||
| M0 | Reference | Reference | ||
| M1 | 8.39 (3.87–18.19) | <0.001 | - | 0.338 |
| Fuhrman Grade | ||||
| I | Reference | Reference | ||
| II | - | 0.891 | - | 0.878 |
| III | - | 0.936 | - | 0.870 |
| IV | - | 0.029 | - | 0.189 |
| ALB | ||||
| Reference | Reference | |||
| 0.155 | - | 0.125 | ||
| NLR | ||||
| Reference | Reference | |||
| 0.709 | - | 0.359 | ||
| PLR | ||||
| Reference | Reference | |||
| 0.233 | - | 0.874 | ||
| SIRI | ||||
| Grade 1 | Reference | Reference | ||
| Grade 2 | 1.91 (0.87–4.21) | 0.109 | 1.27 (0.78–5.04) | 0.513 |
| Grade 3 | 4.93 (2.21–11.00) | <0.001 | 6.29 (2.28–17.39) | <0.001 |
Abbreviations: OS, overall survival; CSS, cancer-specific survival; CI, confidence interval; BMI, body mass index; AJCC, American Joint Committee on Cancer; SIRI, systemic inflammation response index.