Table 2.

Univariate and Multivariate Analysis of Risk Score and Clinical Factors with OS in the Training Cohort and Testing Cohort of TCGA, and External Validation Cohort

Risk Factor	Training Cohort in TCGA (N=259)				Validation Cohort in TCGA (N=111)				External Cohort (N=50)
	Univariate Analysis		Multivariate Analysis		Univariate Analysis		Multivariate Analysis		Univariate Analysis		Multivariate Analysis
	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value
Age	1.009 (0.989–1.029)	0.375	1.008 (0.988–1.028)	0.427	1.010 (0.988–1.032)	0.382	1.006 (0.984–1.028)	0.625	1.052 (0.483–2.289)	0.899	1.432 (1.171–1.917)	0.076
Gender	0.717 (0.434–1.186)	0.195	0.774 (0.455–1.317)	0.346	0.887 (0.495–1.588)	0.686	1.109 (0.594–2.071)	0.745	1.565 (0.718–3.410)	0.260	2.269 (0.8518–6.0429)	0.101
Grade	1.184 (0.835–1.677)	0.343	1.164 (0.799–1.697)	0.428	1.148 (0.787–1.674)	0.473	1.189 (0.791–1.787)	0.405	1.473 (0.470–4.615)	0.506	1.254 (0.340–4.625)	0.734
Stage	1.636 (1.232–2.173)	<0.001	1.451 (1.072–1.963)	0.016	1.706 (1.267–2.299)	<0.001	1.824 (1.335–2.491)	<0.001	2.278 (0.509–10.197)	0.282	1.283 (0.627–2.434)	0.333
RiskScore	1.154 (1.104–1.207)	<0.001	1.138 (1.085–1.193)	<0.001	1.011 (1.003–1.018)	0.005	1.012 (1.003–1.020)	0.008	3.056 (1.857–5.029)	<0.001	4.185 (2.3244–7.5332)	<0.001