Table 2.
ROC curve analysis of various candidates to discriminate between DN and MCNS or MN.
| Candidates | AUC | COP | Specificity | Sensitivity |
|---|---|---|---|---|
| DN vs. MCNS | ||||
| (Set MCNS as positive) | ||||
| SI | 0.9091 | 0.2309 | 0.9091 | 0.8571 |
| uALB | 0.7727 | 930.71 (mg/dL) | 0.9091 | 0.7143 |
| uB2M | 0.7500 | 0.52 (mg/L) | 0.7000 | 0.8182 |
| uRBP4 | 0.8571 | 25.6080 | 1.0000 | 0.7143 |
| uSH3BGRL3 | 0.8571 | 23.1388 | 1.0000 | 0.7143 |
| pITIH1 | 0.9675 | 36.7477 | 0.9091 | 0.9286 |
| uRBP4, uSH3BGRL3 | 0.9740 | −1.6567 | 1.0000 | 0.9286 |
| (04208*[uRBP4] +0.6821*[uSH3BGRL3]-27.9476) | ||||
| uRBP4, pITIH1 | 0.9935 | −1.4938 | 1.0000 | 0.9286 |
| (04238*[uRBP4]-9.4159*[pITIH1] +333.8091) | ||||
| DN vs. MN | ||||
| (Set MN as positive) | ||||
| SI | 0.8538 | 0.3367 | 0.6364 | 0.9130 |
| uALB | 0.5178 | 507.26 (mg/dL) | 0.7273 | 0.4348 |
| uB2M | 0.7136 | 0.39 (mg/L) | 0.7000 | 0.8182 |
| uAFM | 0.7629 | 32.5949 | 1.0000 | 0.4348 |
| uRBP4 | 0.8617 | 24.0587 | 1.0000 | 0.7391 |
| pAPOA2 | 0.9249 | 37.8101 | 0.9091 | 0.8261 |
| u/pC3 | 0.7510 | −12.3763 | 0.9091 | 0.5217 |
| uAFM, uRBP4 | 0.9763 | −1.8943 | 1.0000 | 0.9130 |
| (-1.3560*[uAFM] +0.6013*[uRBP4] +24.4380) | ||||
| uAFM, u/pC3 | 0.9842 | −0.8025 | 1.0000 | 0.9565 |
| (-4.0746*[uAFM] +1.3057*[u/pC3] +137.3265) | ||||
SI: selectivity index; ([urinary IgG]*[plasma TF])/([plasma IgG]* [urinary TF]). The uALB and uB2M are biomarkers for glomerular and tubular disorders, respectively. Those that are superior to SI, uALB, and uB2M are shown in bold. The same values as the best among these biomarkers are underlined. COP: cut off point.