Fig. 5.

In vivo antitumor effect of osteosarcoma in nude mice. (A) Illustration of photothermal therapy in nude mice. (B) In vivo fluorescence imaging and biodistribution of nude mice bearing osteosarcoma at different time points after intravenous injection. (C) Representative images of tumor-bearing nude mice after treated with varied groups under magnetic field: (1) (PB+DOX)@(Fe₃O₄@PEG-PLGA) MCs + NIR laser; (2) (PB+DOX)@(Fe₃O₄@PEG-PLGA) MCs; (3) PB@(Fe₃O₄@PEG-PLGA) MCs + NIR laser; (4) PB@(Fe₃O₄@PEG-PLGA) MCs; (5) DOX; (6) Saline. (D) Pictures of tumors obtained from nude mice on day 28 after receiving different treatments. Changes of (E) body weights and (F) tumor volumes after treatments for 28 days (n = 6). ***p < 0.001. (G) Survival rate of osteosarcoma tumor-bearing nude mice as a function of time after treatments (n = 8).