Table 2.
Summary of the effect of osteoporosis on fracture healing in clinical studies.
| Author | Study design | Fracture location | n (patients/control) | Effect | Bias |
|---|---|---|---|---|---|
| v Wunnik [29] | Prospective matched controlled | Various | 120 (40/80) | No effect on incidence of non-union | Variety of fractures location Small number of patients |
| Zura [27] | Prospective cohort | Various | 56,492 (1440/55,052) | ↑ risk of non-union (multivariate analysis OR 1.423, Robust SE 0.108; p < 0.001) | Variety of fractures location Insurance database |
| Zura [28] | Inception cohort | Various | 309,330 (15,249/294,081) | ↑ risk of non-union (multivariate analysis OR 1.24, 95% CI (1.14–1.34)) | Variety of fractures location Insurance database |
| Nikolaou [30] | Retrospective | Femoral shaft | 66 (29/37) | ↑ time to union (19.4 weeks vs 16.2 weeks, p = 0.02) and delayed union (10/29 vs 4/37 p = 0.03) No effect on incidence of non-union |
Selection/inclusion Small number of patients No correction for age |
| Gorter [31] | Retrospective | Subcapital humerus and distal radius | 455 (133/322) | No clear effect on delayed or non-union | Retrospective design Small number of patient in subgroup Outcome parameter |
↑ significant increased, ↓ significant decreased.