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. 2021 Aug 5;15:101115. doi: 10.1016/j.bonr.2021.101115

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — Differential expression of tiRNAs in callus tissue. (A) Volcano plots visualize the expression levels of a total of 191 annotated tiRNAs with average normalized read counts (baseMean) above 1000. Green dots represent downregulated genes (P_adjusted-value < 0.05 and log2FC < −2), red dots represent upregulated genes (P_adjusted-value < 0.05 and log2FC > 2) and grey dots represent other genes (X-axis, absolute value of log2FC > 2 and P_adjusted-value > 0.05). Horizontal dotted lines represent P_adjusted-value threshold (0.05) and vertical dotted lines represent log2FC thresholds (−2 and 2). (B) Distribution of normalized expression levels of six differentially expressed mature tiRNAs with average normalized read counts (baseMean) > 1000, log2 fold change > 2 and P_adjusted-value < 0.05 during fracture healing. Samples are D0 control bone (n = 4), and callus samples at D5 (n = 3), D7 (n = 5), D10 (n = 4), and D14 (n = 2).