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. 2021 Aug 14;7(8):e07804. doi: 10.1016/j.heliyon.2021.e07804

Figure 2.

Figure 2

Genetic findings in the patient. (A) Location of mutations in ADH5 and ALDH2. (B) Family pedigree, patient. Symbols for clinically unaffected individuals are empty (circle, female; square, male). The symbol, a square, for the patient is filled. M1 and M2 indicate the mutant alleles of ADH5, whereas W indicates a wild-type allele. (C and D) Sanger sequencing results, ADGRV1 variants in the patient. In C, a chromatogram is abnormal; the arrow indicates the duplicated nucleotide within ADGRV1, i.e., c.448_449dup. In D, achromatogram again is abnormal; the arrow indicates the site at which a nucleotide within ADGRV1 has been deleted, i.e., c.18295del. (E) ADGRV1 variants were identified in a non-consanguine family. Symbols for clinically unaffected individuals are empty (circle, female; square, male). The symbol, a square, for the patient is filled. M1 and M2 indicate the mutant alleles of ADGRV1, whereas W indicates a wild-type allele.