Table 2.

Bioinformatic selection of miR-9-5p predicted targets.

GENE	SYMBOL	REPRESENTATIVE TRANSCRIPT	PREDICTION DATABASES	BINDING POSITION ON THE 3′UTR	LITERATURE EVIDENCE
Dopamine Receptor D2	DRD2	ENSMUST00000075764.6	A	285–292	-Stress response: Żurawek et al., (2013) -Depression and antidepressant response: He et al., 2019, Pecina et al., 2017, Wang et al., 2012
ELAV like RNA binding protein 1	ELAVL1	ENSMUST00000098950.4	A, B, C	788–795	-Stress response: He et al. (2019) -Depression and antidepressant response: He et al. (2019)
Glycogen Synthase Kinase 3, β	GSK3β	ENSMUST00000023507.7	A	3565–3571	-Stress response: Aceto et al., (2020) -Depression and antidepressant response: Duman and Aghajanian, 2014, Liu et al., 2013, Zarate and Machado-Vieira, 2016
Neurotrophic Receptor Tyrosine Kinase 3	NTRK3	ENSMUST00000039431.8	A	1741–1749	-Stress response: Farhang et al., 2014, Xu et al., 2015 -Depression and antidepressant response: Tamasi et al. (2014)
RE-1 Silencing Transcription Factor	REST	ENSMUST00000080359.6	A, C	1749-1755; 3207–3213	-Stress response: Mampay et al., (2019); Soga et al., (2021) -Depression and antidepressant response: Soga et al., (2021) -Morphology: Giusti et al., (2014)
Sirtuin 1	SIRT1	ENSMUST00000120239.2	A, B, C	335–342	-Stress response: Kim et al., 2016, Liu et al., 2019, Shen et al., 2019 -Depression and antidepressant response: Abe-Higuchi et al., (2016); Nan et al. (2020) -Morphology: Codocedo et al. (2012); Michan et al., (2010)
Sortilin 1	SORT1	ENSMUST00000102632.5	A, B, C	3274–3280	-Stress response: Bai et al., 2016, Ruan et al., 2016 -Depression and antidepressant response: Yang et al. (2020)

Putative targets of miR-9-5p were bioinformatically identified using TargetScan (A), MirDB (B) and microT-CDS (C). Genes relevant to our study were selected based on their recognized role in synaptic plasticity, response to stress, depression, and antidepressant drugs response.