Figure 7.

Genes with higher allelic bursting coordination enriched for gene sets with developmental functions

(A) Scatterplot representing different categories of the genes based on allelic transcriptional bursting in EPI and VE cells of E6.5: low p0 high p2 (green asterisk), highly coordinated (genes with p0+p2 ≥ 0.90: slate gray square within blue dotted lines), independent (genes near the red curve line; with a threshold ±0.05 [upper and lower red curve line] from the main red curve lines: rosewood triangle), and semicoordinated (Persian green dots).

(B) Gene ontology biological process representing enrichment of highly coordinated genes (EPI, E6.5) in different developmental processes.

(C) Venn diagram representing the common genes between EPI E6.5 and VE E6.5 cells.

(D) Scatterplot representing different categories of the genes (low p0 high p2, highly coordinated, independent, and semicoordinated) based on allelic transcriptional bursting in EPI and VE cells of E6.5.

(E) Cross-comparison of the degree of coordination between EPI E6.5 and VE E6.5 cells based on different categories (genes with low p0 high p2, highly coordinated, independent, and semicoordinated) of allelic burst kinetics.