Table 1.
Summary of subject characteristics for samples retained after QC and PCA analysis
| DLPFC samples | C | SCZ | BP | Statistics (χ 2/ANOVA) |
|---|---|---|---|---|
| Number | 82 | 57 | 35 | |
| Sex | 59 M, 23 F | 44 M, 13 F | 20 M, 15 F | χ 2 = 4.33, P = .12 |
| Age (years) | 48.1 ± 14.2 | 48.1 ± 13.0 | 45.5 ± 12.2 | F(2,171) = 0.52, P = .60 |
| PMI (hours) | 19 ± 5.4 | 20.0 ± 8.4 | 20.5 ± 7.0 | F(2,171) = 0.71, P = .50 |
| RIN | 8.5 ± 0.4 | 8.2 ± 0.6* | 8.2 ± 0.5* | F(2,171) = 9.82, P = 9.0 × 10−5 |
| pH | 6.7 ± 0.3 | 6.6 ± 0.3 | 6.6 ± 0.3 | F(2,171) = 3.0, P = .052 |
| ACC samples | ||||
| Number | 77 | 57 | 32 | |
| Sex | 54 M, 23 F | 44 M, 13 F | 19 M, 13 F | χ 2 = 2.52, P = .28 |
| Age (years) | 48.0 + 14.5 | 47.4 + 13.2 | 45.5 + 12.5 | F(2,163) = 0.37, P = .69 |
| PMI (hours) | 18.9 + 5.3 | 19.3 + 8.0 | 20.5 + 6.7 | F(2,163) = 0.69, P = .50 |
| RIN | 7.9 + 0.6 | 7.6 + 0.7* | 7.5 + 0.8* | F(2,163) = 3.83, P = .02 |
| pH | 6.7 ± 0.3 | 6.6 ± 0.3* | 6.6 ± 0.3* | F(2,163) = 4.0, P = .02 |
Note: Values are mean (standard deviation).
DLPFC, dorsolateral prefrontal; SCZ, schizophrenia; BP, bipolar disorder; ANOVA, analysis of variance; PMI, postmortem interval; RIN, RNA integrity number obtained for samples isolated for RNA sequencing; ACC, anterior cingulated; SA, schizoaffective disorder; BP + P, bipolar disorder subjects with psychosis; BP – P, bipolar disorder subjects without psychosis; QC, quality control; PCA, principal component analysis.
*Significantly different from C subjects.