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Prenatal kynurenine treatment prolongs wakefulness and reduces activity in females. Data are represented by phase: (A) wake duration; (B) number of wake bouts; (C) average wake bout duration; (D) a heat map depicting relative cage activity levels per 1-h bin; (E) relative cage activity by phase. Data are mean ± SEM. Repeated-measures 2-way ANOVA analyses followed by Bonferroni’s post hoc test: *P < .05, **P < .001; Data are mean ± SEM; n = 6–11 litters per group.
