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Brain KYNA is elevated in male EKyn offspring and KAT activity is reduced in female EKyn offspring. (A) Brain KYNA; (B) Brain KAT I activity; (C) Brain KAT II activity; (D) plasma tryptophan; (E) Plasma kynurenine; (F) Plasma KYNA were assessed at ZT 6 and ZT18. Data are mean ± SEM. Repeated-measures ANOVA with Bonferroni’s post hoc test: *P < .05, ***P < .001; n = 7–8 per group.
