Table 2.
MNI Coordinates | ||||||||
---|---|---|---|---|---|---|---|---|
Cerebellar Seeds | Direction of Association | Regions | P (FWE-Corr) | Cluster Size | x | y | z | T |
A. Patients with schizophrenia | ||||||||
CNI MC | ||||||||
Crus Iexe1 | Positive | Inferior frontal gyrus | .001 | 123 | 56 | 8 | 18 | 5.54 |
Crus IIexe3 | Negative | Inferior temporal gyrus | .001 | 126 | −44 | 6 | −36 | 4.47 |
Lobule VIIImot4 | Positive | Precuneus | <.001 | 195 | −4 | −54 | 34 | 5.64 |
CNI SI | No significant results | |||||||
CNI DIS | No significant results | |||||||
CNI total | ||||||||
Crus IIexe3 | Negative | Inferior temporal gyrus | .003 | 106 | −46 | 8 | −40 | 4.66 |
Crus IIexe4 | Negative | Inferior temporal gyrus | .003 | 110 | −46 | 10 | −40 | 5.13 |
Lobule Vmot2 | Positive | Precuneus | .001 | 121 | −8 | −50 | 38 | 5.21 |
B. Healthy controls | ||||||||
CNI MC | ||||||||
Crus Iexe1 | Positive | Middle occipital gyrus | .001 | 130 | −46 | −78 | 28 | 5.4 |
Positive | Precuneus | .001 | 128 | −12 | −64 | 30 | 4.51 | |
Negative | Superior temporal gyrus | <.001 | 339 | −62 | −2 | −2 | 5.82 | |
Negative | Postcentral gyrus | .004 | 101 | 60 | −10 | 24 | 5.33 | |
Crus Iexe2 | Negative | Superior temporal gyrus | .0046 | 98 | −64 | −8 | 8 | 4.7 |
Lobule VIexe5 | Negative | Medial superior frontal gyrus | .0046 | 95 | 10 | 54 | 40 | 5.3 |
Lobule VIIImot4 | Positive | Middle occipital gyrus | <.001 | 180 | −22 | −78 | 12 | 4.77 |
Positive | Middle occipital gyrus | <.001 | 129 | 28 | −68 | 18 | 4.47 | |
CNI SI | ||||||||
Crus Iexe2 | Positive | Fusiform gyrus | .001 | 121 | −26 | −42 | −12 | 5.15 |
Crus IIexe3 | Positive | Precuneus | .004 | 100 | 24 | −50 | 18 | 5.34 |
Positive | Fusiform gyrus | .003 | 101 | −26 | −44 | −12 | 5.05 | |
Positive | Fusiform gyrus | .001 | 125 | 30 | −44 | −14 | 4.83 | |
Crus IIexe4 | Positive | Inferior parietal lobule | <.001 | 141 | 30 | −46 | 40 | 5.03 |
Lobule VIexe5 | Negative | Fusiform gyrus | <.001 | 299 | −34 | −38 | −16 | 5.49 |
Negative | Fusiform gyrus | <.001 | 139 | 30 | −42 | −20 | 4.98 | |
Lobule VIIImot3 | Positive | Superior frontal gyrus | .002 | 100 | 30 | 60 | −2 | 4.5 |
CNI DIS | ||||||||
Lobule VIIImot3 | Positive | Calcarine sulcus | <.001 | 132 | −6 | −100 | −8 | 5.84 |
CNI total | ||||||||
Crus Iexe1 | Positive | Cuneus | <.001 | 304 | −20 | −58 | 22 | 5.77 |
Positive | Middle occipital gyrus | .001 | 118 | −44 | −74 | 24 | 5.25 | |
Negative | Middle occipital gyrus | .002 | 109 | 38 | −86 | 8 | 5.11 | |
Negative | Superior temporal gyrus | <.001 | 170 | −60 | 4 | 4 | 4.55 |
Note: CNI, the abridged version of the Cambridge Neurological Inventory; MC, motor coordination subscale; SI, sensory integration subscale; DIS, disinhibition subscale. The brain regions in bold were validated in the replication dataset. The threshold was voxel-level P < .001 and cluster-level FWE correction P < .005.