Table 3.
Comparisons of responses to iEPO between high and low concentration delivery strategies
| iEPO indications | High concentration delivery | Low concentration delivery | p | ||||
|---|---|---|---|---|---|---|---|
| Pre | Post | p | Pre | Post | p | ||
| Overall | |||||||
| HR, beats/min | 101.6 ± 20.7 | 100.7 ± 21.2 | 0.496 | 103.9 ± 19.6 | 102.7 ± 18.9 | 0.301 | 0.949 |
| RR, breaths/min | 24.0 ± 7.4 | 24.1 ± 6.4 | 0.923 | 25.5 ± 7.4 | 25.1 ± 7.3 | 0.373 | 0.964 |
| mBP, mm Hg | 77.3 (69.3, 85) | 75.0 (68.0, 84.0) | 0.158 | 74 (67.8, 84.5) | 75 (70.0, 82.2) | 0.669 | 0.773 |
| Hypoxemia (n = 58 high concentration vs 56 low concentration) | |||||||
| SpO2/FIO2 | 89.5 (84, 102.5) | 99 (91.8, 134.6) | < 0.001 | 93.5 (88, 106.4) | 98.5(93, 121.3) | < 0.001 | 0.436 |
| PaO2/FIO2, mm Hga | 67(57, 101.4) | 113.3 (78.9, 169.2) | < 0.001 | 73 (59, 88.8) | 107.5 (77.8, 148.3) | < 0.001 | 0.948 |
| PEEP, cm H2O | 13.0 ± 4.2 | 13.3 ± 4.6 | 0.403 | 13.2 ± 5.0 | 12.9 ± 4.6 | 0.263 | 0.197 |
| Pulmonary hypertension (n = 30 high concentration vs 25 low concentration) | |||||||
| mPAP, mmHgb | 39.1 ± 11.6 | 34.5 ± 10.3 | 0.012 | 36.7 ± 9.0 | 31.7 ± 7.3 | 0.019 | 0.551 |
| CO, L/minc | 4.2 ± 0.5 | 5.3 ± 1.1 | 0.003 | 6.3 ± 2.1 | 6.0 ± 1.8 | 0.635 | 0.337 |
| CI, L/min/m2 d | 2.22 ± 0.32 | 2.75 ± 0.70 | 0.006 | 3.23 ± 1.24 | 2.97 ± 0.92 | 0.593 | 0.231 |
| SvO2, %e | 65.6 ± 15.5 | 67.1 ± 15.4 | 0.131 | 65.2 ± 12.2 | 64.9 ± 8.3 | 1.0 | 0.429 |
| Right heart failure (n = 20 high concentration vs 14 low concentration) | |||||||
| mPAP, mmHgf | 33.4 ± 14 | 29.8 ± 10.3 | 0.094 | 29.9 ± 7.1 | 27.6 ± 3.8 | 0.283 | 0.979 |
| CO, L/ming | 4.4 ± 0.6 | 5.5 ± 1.1 | 0.011 | 6.2 ± 3.1 | 6.2 ± 2.4 | 1.0 | 0.359 |
| CI, L/min/m2 h | 2.32 ± 0.37 | 2.89 ± 0.56 | 0.008 | 3.20 ± 2.06 | 2.95 ± 1.32 | 0.606 | 0.141 |
| SvO2, %i | 67.2 ± 10.8 | 68.2 ± 10.5 | 0.426 | 67.8 ± 14.7 | 65.8 ± 13.4 | 0.236 | 0.142 |
iEPO inhaled epoprostenol, HR heart rate, RR respiratory rate, mBP mean blood pressure, mPAP mean pulmonary arterial pressure, SpO2 saturation of pulse oximetry, FIO2 fraction of inspired oxygen, PaO2 partial pressure of arterial oxygen, PEEP positive end expiratory pressure, CO cardiac output, CI cardiac index, SvO2 saturation of mixed venous oxygen
aData was available in 45 and 35 patients in intermittent and continuous delivery group, respectively
bData was available in 22, 15 patients in two groups
cData was available in 12, 9 patients in two groups
dData was available in 13, 9 patients in two groups
eData was available in 7, 10 patients in two groups
fData was available in 14, 7 patients in two groups
gData was available in 8, 4 patients in two groups
hData was available in 9, 4 patients in two groups
iData was available in 6, 4 patients in two groups