Fig. 2.

Validation of the glyco-signature on ICGC patient's cohort (RNA-seq). (a) Two-dimension representation of the HCPC analysis results and (b) cluster dendrogram related to ICGC RNA-seq data (n = 91) using 19 GT genes. (c) Survival curves estimated by using the Kaplan-Meier method and comparing OS probabilities between clusters with the log-rank test (p-value = 0.0042). Cluster 1 and 2 have shorter median OS of 304 and 359 days, respectively compared to cluster 3 with median OS of 719 days. (d) Mosaic plot showing cross-link between basal-like/classical subtypes and clusters 1, 2 and 3 identified through GT gene prognostic markers. Box height reflects the number of tumors classified in each cluster and box width represents proportion of basal-like/classical subtypes (p-value < 0.0001, Fisher's exact test).