Table 1. Demographic and Clinical Characteristics of Patients With Extremity Soft-Tissue Sarcoma in the National Cancer Database.
| Characteristic | Patients, No. (%) | P valuea | |||
|---|---|---|---|---|---|
| Total (N = 8953) | Age, y | ||||
| 18-39 (n = 1280) | 40-64 (n = 3937) | ≥65 (n = 3736) | |||
| Radiation | |||||
| No RT | 3106 (34.7) | 521 (40.7) | 1218 (30.9) | 1367 (36.6) | <.001 |
| RT | 5847 (65.3) | 759 (59.3) | 2719 (69.1) | 2369 (63.4) | |
| RT type | |||||
| No RT | 3106 (34.7) | 521 (40.7) | 1218 (30.9) | 1367 (36.6) | <.001 |
| Preoperative RT | 1801 (20.1) | 235 (18.4) | 891 (22.6) | 675 (18.1) | |
| Postoperative RT | 4046 (45.2) | 524 (40.9) | 1828 (46.4) | 1694 (45.3) | |
| Chemotherapy | |||||
| None | 6689 (74.7) | 739 (57.7) | 2667 (67.7) | 3283 (87.9) | <.001 |
| Given | 2012 (22.5) | 504 (39.4) | 1161 (29.5) | 347 (9.3) | |
| Unknown | 252 (2.8) | 37 (2.9) | 109 (2.8) | 106 (2.8) | |
| Treatment | |||||
| Amputation | 520 (5.8) | 104 (8.1) | 217 (5.5) | 199 (5.3) | <.001 |
| LSS with or without RT | 8433 (94.2) | 1176 (91.9) | 3720 (94.5) | 3537 (94.7) | |
| Sex | |||||
| Male | 4796 (53.6) | 708 (55.3) | 2239 (56.9) | 1849 (49.5) | <.001 |
| Female | 4157 (46.4) | 572 (44.7) | 1698 (43.1) | 1887 (50.5) | |
| Race/ethnicity | |||||
| White Non-Hispanic | 6615 (73.9) | 780 (60.9) | 2855 (72.5) | 2980 (79.8) | <.001 |
| White Hispanic | 557 (6.2) | 166 (13.0) | 260 (6.6) | 131 (3.5) | |
| Black | 921 (10.3) | 192 (15.0) | 464 (11.8) | 265 (7.1) | |
| Other or unknownb | 860 (9.6) | 142 (11.1) | 358 (9.1) | 360 (9.6) | |
| Insurance status | |||||
| Not insured | 375 (4.2) | 125 (9.8) | 229 (5.8) | 21 (0.6) | <.001 |
| Private insurance | 4355 (48.6) | 873 (68.2) | 3020 (76.7) | 462 (12.4) | |
| Medicaid | 524 (5.9) | 198 (15.5) | 270 (6.9) | 56 (1.5) | |
| Medicare | 3425 (38.3) | 38 (3.0) | 267 (6.8) | 3120 (83.5) | |
| Other or unknown | 274 (3.1) | 46 (3.6) | 151 (3.8) | 77 (2.1) | |
| Median income in patient’s zip code in 2012, $ | |||||
| <38 000 | 1460 (16.3) | 233 (18.2) | 657 (16.7) | 570 (15.3) | .009 |
| 38 000-$47 999 | 2033 (22.7) | 278 (21.7) | 873 (22.2) | 882 (23.6) | |
| 48 000-$62 999 | 2369 (26.5) | 347 (27.1) | 984 (25.0) | 1038 (27.8) | |
| ≥63 000 | 2949 (32.9) | 405 (31.6) | 1361 (34.6) | 1183 (31.7) | |
| Unknown | 142 (1.6) | 17 (1.3) | 62 (1.6) | 63 (1.7) | |
| Non–high school graduates, % of population in patient’s zip code | |||||
| ≥21 | 1466 (16.4) | 251 (19.6) | 694 (17.6) | 521 (13.9) | <.001 |
| 13-20.9 | 2140 (23.9) | 300 (23.4) | 903 (22.9) | 937 (25.1) | |
| 7-12.9 | 2911 (32.5) | 419 (32.7) | 1260 (32.0) | 1232 (33.0) | |
| <7 | 2308 (25.8) | 296 (23.1) | 1027 (26.1) | 985 (26.4) | |
| Unknown | 128 (1.4) | 14 (1.1) | 53 (1.3) | 61 (1.6) | |
| Living location | |||||
| Metropolitanc | 4500 (50.3) | 668 (52.2) | 2055 (52.2) | 1777 (47.6) | <.001 |
| Smaller metropolitanc | 2699 (30.1) | 397 (31.0) | 1125 (28.6) | 1177 (31.5) | |
| Urban | 1289 (14.4) | 164 (12.8) | 558 (14.2) | 567 (15.2) | |
| Rural | 139 (1.6) | 11 (0.9) | 64 (1.6) | 64 (1.7) | |
| Unknown | 326 (3.6) | 40 (3.1) | 135 (3.4) | 151 (4.0) | |
| Distance to reporting facility, miles | |||||
| ≤10 | 3145 (35.1) | 404 (31.6) | 1357 (34.5) | 1384 (37.0) | .004 |
| 11-20 | 1652 (18.5) | 250 (19.5) | 758 (19.3) | 644 (17.2) | |
| 21-50 | 1798 (20.1) | 258 (20.2) | 815 (20.7) | 725 (19.4) | |
| >50 | 2232 (24.9) | 355 (27.7) | 952 (24.2) | 925 (24.8) | |
| Unknown | 126 (1.4) | 13 (1.0) | 55 (1.4) | 58 (1.6) | |
| Comorbidity, No. | |||||
| 0 | 7360 (82.2) | 1214 (94.8) | 3374 (85.7) | 2772 (74.2) | <.001 |
| 1 | 1303 (14.6) | 61 (4.8) | 471 (12.0) | 771 (20.6) | |
| 2 | 290 (3.2) | 5 (0.4) | 92 (2.3) | 193 (5.2) | |
| Transition in care | |||||
| No | 1358 (15.2) | 212 (16.6) | 571 (14.5) | 575 (15.4) | <.001 |
| Yes | 4851 (54.2) | 683 (53.4) | 2174 (55.2) | 1994 (53.4) | |
| Unknown | 2744 (30.6) | 385 (30.1) | 1192 (30.3) | 1167 (31.2) | |
| Primary site | |||||
| Upper limb | 2188 (24.4) | 338 (26.4) | 878 (22.3) | 972 (26.0) | <.001 |
| Lower limb | 6765 (75.6) | 942 (73.6) | 3059 (77.7) | 2764 (74.0) | |
| Grade | |||||
| MD | 1125 (12.6) | 229 (17.9) | 519 (13.2) | 377 (10.1) | <.001 |
| PD | 4698 (52.5) | 666 (52.0) | 2037 (51.7) | 1995 (53.4) | |
| UD | 3130 (35.0) | 385 (30.1) | 1381 (35.1) | 1364 (36.5) | |
| Tumor size, cm | |||||
| ≤5.00 | 2610 (29.2) | 409 (32.0) | 1117 (28.4) | 1084 (29.0) | <.001 |
| 5.01-10.00 | 3288 (36.7) | 480 (37.5) | 1392 (35.4) | 1416 (37.9) | |
| 10.01-15.00 | 1690 (18.9) | 240 (18.8) | 774 (19.7) | 676 (18.1) | |
| >15.00 | 1365 (15.2) | 151 (11.8) | 654 (16.6) | 560 (15.0) | |
| Clinical tumor stage | |||||
| I | 1935 (21.6) | 301 (23.5) | 824 (20.9) | 810 (21.7) | .34 |
| II | 4978 (55.6) | 704 (55.0) | 2210 (56.1) | 2064 (55.2) | |
| Unknown | 2040 (22.8) | 275 (21.5) | 903 (22.9) | 862 (23.1) | |
| Depth of extension | |||||
| Superficial | 2324 (26.0) | 301 (23.5) | 956 (24.3) | 1067 (28.6) | <.001 |
| Deep | 5873 (65.6) | 850 (66.4) | 2657 (67.5) | 2366 (63.3) | |
Abbreviations: LSS, limb-sparing surgery; MD, moderately differentiated; PD, poorly differentiated; RT, radiation therapy; UD, undifferentiated.
a
P value derived from χ2 test.
b
Other races/ethnicities included American Indian, Aleutian, or Eskimo; Chinese; Japanese; Filipino; Hawaiian; Korean; Vietnamese; Laotian; Hmong; Kampuchean; Thai; Asian Indian or Pakistani, not otherwise specified; Asian Indian; Pakistani; Micronesian, not otherwise specified; Chamorran; Guamanian, not otherwise specified; Polynesian, not otherwise specified; Tahitian, Samoan, Tongan, Melanesian, not otherwise specified; Fiji Islander; New Guinean; other Asian, including Asian, not otherwise specified, and Oriental, not otherwise specified; and Pacific Islander, not otherwise specified.
c
Metropolitan was defined as having a population of 250 000 or greater; smaller metropolitan, 20 000 to less than 250 000.