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Top docking solutions of (R)-MDMA (in magenta) and (S)-MDMA (in green) at the central site of the human 5HT transporter (hSERT) superimposed to the Cryo-EM structure bound to paroxetine (in translucent grey) PDB: 6VRH. Of note, the 1,3-benzodioxol moieties of the MDMA isomers overlap exactly on the benzodioxol of paroxetine and can distinguished by its grey coloured translucent atom balls. The asterisks are at the chiral centre of each isomer. Sub-sites A, B and C are in grey.
