Table 4.
TILs in dMMR and PMMR ECs
| Variable | dMMR (N=12) | PMMR (N=70) | P | ||
|---|---|---|---|---|---|
| Mean (SD) | Median | Mean (SD) | Median | ||
| Mean CD3 (cells/mm2) | |||||
| Glands | 204.4 (242.8) | 113.5 | 152.5 (178.7) | 92.5 | 0.281 |
| Interstitium | 433.0 (275.2) | 275.2 | 459.6 (309.5) | 409.5 | 0.781 |
| Hotspot | 774.3 (509.6) | 509.6 | 759.9 (555.1) | 673 | 0.933 |
| Center | 571.8 (458.7) | 458.7 | 531.6 (360.8) | 455.5 | 0.734 |
| Periphery | 593.4 (494.0) | 494.1 | 555.5 (469.6) | 424.5 | 0.799 |
| Mean CD8 (cells/mm2) | |||||
| Glands | 54.9 (45.1) | 43 | 59.9 (74.6) | 34 | 0.508 |
| Interstitium | 76.6 (45.7) | 70.5 | 164.2 (171.4) | 91.5 | 0.081 |
| Hotspot | 163.4 (81.2) | 157.5 | 257.9 (272.8) | 149.5 | 0.713 |
| Center | 97.0 (79.7) | 84 | 152.3 (162.2) | 98.5 | 0.276 |
| Periphery | 124.1 (52.9) | 122 | 205.6 (233.0) | 119 | 0.793 |
Abbreviations: dMMR, deficient mismatch repair; PMMR, proficient mismatch repair.