Table 5.
TILs in ECs with or without Positive PD-L1 Expression in Tumor Cells (Cutoff Value: 1%)
| Variable | PD-L1-Negative Tumor | PD-L1-Positive Tumor | P | ||
|---|---|---|---|---|---|
| N = 23 | N = 75 | ||||
| Mean (SD) | Median | Mean (SD) | Median | ||
| Mean CD3 (cells/mm2) | |||||
| Glands | 55.5 (41.2) | 45.5 | 184.9 (197.2) | 115.5 | <0.0001 |
| Interstitium | 381.2 (363.5) | 328 | 492.3 (300.6) | 454 | 0.15 |
| Hotspot | 547.9 (509.0) | 380.5 | 856.6 (539.1) | 754.5 | 0.019 |
| Centre | 371.6 (315.2) | 302 | 582.9 (374.1) | 496 | 0.018 |
| Periphery | 444.8 (583.0) | 310 | 627.6 (478.6) | 537.5 | 0.02 |
| Mean CD8 (cells/mm2) | |||||
| Glands | 39.1 (70.8) | 18 | 63.6 (64.3) | 47.5 | 0.001 |
| Interstitium | 118.7 (136.8) | 72 | 159.7 (160.1) | 94 | 0.054 |
| Hotspot | 168.5 (192.4) | 116 | 277.7 (260.8) | 191.5 | 0.005 |
| Centre | 110.9 (126.3) | 83 | 157.2 (154.2) | 109 | 0.03 |
| Periphery | 129.6 (166.4) | 85 | 212.4 (220.3) | 143.5 | 0.005 |
Abbreviations: TILs, tumor-infiltrating lymphocytes; EC, endometrial cancer.