Table 7.
TILs in ECs with or without Positive PD-L1 Expression in Tumor Cells (Cutoff Value: 5%)
| Variable | PD-L1-Negative Tumor Cells | PD-L1-Positive Tumor Cells | P | ||
|---|---|---|---|---|---|
| N = 46 | N = 52 | ||||
| Mean (SD) | Median | Mean (SD) | Median | ||
| Mean CD3 (cells/mm2) | |||||
| Glands | 94.1 (107.5) | 53 | 209.1 (216.1) | 131 | 0 |
| Interstitium | 377.1 (309.9) | 335 | 546.0 (305.6) | 475 | 0.009 |
| Hotspot | 589.2 (471.9) | 462 | 959.4 (551.3) | 860 | 0.001 |
| Centre | 410.8 (324.2) | 341 | 643.7 (377.8) | 607 | 0.002 |
| Periphery | 463.9 (508.1) | 310 | 693.2 (486.0) | 627 | 0.002 |
| Mean CD8 (cells/mm2) | |||||
| Glands | 42.5 (55.8) | 26.5 | 71.6 (72.4) | 50 | 0.001 |
| Interstitium | 123.0 (114.6) | 79.5 | 174.3 (182.1) | 94 | 0.165 |
| Hotspot | 189.6 (174.1) | 126 | 307.9 (292.8) | 195 | 0.005 |
| Centre | 122.2 (115.4) | 86 | 167.9 (171.8) | 114 | 0.08 |
| Periphery | 147.0 (147.3) | 100.5 | 233.9 (249.6) | 149 | 0.008 |
Abbreviations: TILs, tumor-infiltrating lymphocytes; EC, endometrial cancer.