Table 3.

The pathways of the differential metabolites enriched

Pathway name	Match status	p value	− log (p)	Impact
Glycerophospholipid metabolism	4/36	0.00555	5.1945	0.26445
Sphingolipid metabolism	3/21	0.00826	4.7961	0.06896
Arginine biosynthesis	2/14	0.03220	3.4358	0.11675
Histidine metabolism	2/16	0.04139	3.1848	0.00000
Ether lipid metabolism	2/20	0.06227	2.7763	0.14458
Aminoacyl-tRNA biosynthesis	3/48	0.07376	2.6069	0.00000
Phenylalanine, tyrosine and tryptophan biosynthesis	1/4	0.08013	2.5241	0.50000
Linoleic acid metabolism	1/5	0.09917	2.3109	0.00000
Alanine, aspartate and glutamate metabolism	2/28	0.11195	2.1897	0.42068
Nitrogen metabolism	1/6	0.11783	2.1385	0.00000
d-Glutamine and d-glutamate metabolism	1/6	0.11783	2.1385	0.50000
Purine metabolism	3/65	0.14751	1.9139	0.03102
Ascorbate and aldarate metabolism	1/8	0.15403	1.8706	0.00000
Taurine and hypotaurine metabolism	1/8	0.15403	1.8706	0.42857
Phenylalanine metabolism	1/10	0.18879	1.6671	0.35714
Alpha-Linolenic acid metabolism	1/13	0.23835	1.4340	0.00000
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/14	0.25420	1.3696	0.00399
Butanoate metabolism	1/15	0.26974	1.3103	0.00000
Nicotinate and nicotinamide metabolism	1/15	0.26974	1.3103	0.00000
Glycerolipid metabolism	1/16	0.28496	1.2554	0.01402
Pantothenate and CoA biosynthesis	1/19	0.32881	1.1123	0.00000
Beta-Alanine metabolism	1/21	0.35659	1.0312	0.00000
Pyruvate metabolism	1/22	0.37005	0.9941	0.08398
Glutathione metabolism	1/28	0.44529	0.8090	0.01966
Porphyrin and chlorophyll metabolism	1/30	0.46838	0.7585	0.00000
Glyoxylate and dicarboxylate metabolism	1/32	0.49054	0.7123	0.00000
Cysteine and methionine metabolism	1/33	0.50128	0.6906	0.00000
Arachidonic acid metabolism	1/36	0.53220	0.6307	0.00000
Arginine and proline metabolism	1/38	0.55177	0.5946	0.08600
Fatty acid degradation	1/39	0.56126	0.5776	0.00000
Steroid biosynthesis	1/42	0.58856	0.5301	0.00000
Primary bile acid biosynthesis	1/46	0.62242	0.4741	0.00758