Table 3.
Enrichment analysis of the third trimester group
| Pathway associated metabolite sets | Enriched compounds | Total | Hits | Raw p | Holm p | FDR |
|---|---|---|---|---|---|---|
| Urea cycle |
Pyruvic acid; Oxoglutaric acid; L-Alanine; L-Arginine;L-Glutamine Citrulline |
29 | 6 | 0.000325 | 0.0318 | 0.0176 |
| Ammonia recycling |
Glycine; L-Histidine; L-Glutamine; L-Serine; Oxoglutaric acid; Pyruvic acid |
32 | 6 | 0.000574 | 0.0557 | 0.0176 |
| Glycine and serine metabolism |
Glycine;Guanidoacetic acid;Pyruvic acid;L-Alanine;L-Serine;L-Arginine Oxoglutaric acid; L-Methionine |
59 | 8 | 0.000638 | 0.0612 | 0.0176 |
| Valine-leucine-isoleucine degradation |
Alpha-ketoisovaleric acid; L-Valine; Methylmalonic acid; Oxoglutaric acid; Succinic acid; Ketoleucine; 3-Methyl-2-oxovaleric acid; L- Leucine |
60 | 8 | 0.000718 | 0.0682 | 0.0176 |
| Arginine and proline metabolism |
Glycine; Guanidoacetic acid; L- Proline; Oxoglutaric acid; Succinic acid; L-Arginine; Citrulline |
53 | 7 | 0.00173 | 0.163 | 0.034 |
| Alanine metabolism |
Glycine; Oxoglutaric acid; Pyruvic acid; L-Alanine |
17 | 4 | 0.00221 | 0.206 | 0.0362 |
| Glutamate metabolism |
Glycine; L-Alanine; Oxoglutaric acid; Pyruvic acid; Succinic acid; L-Glutamine |
49 | 6 | 0.00571 | 0.525 | 0.0747 |
| Aspartate metabolism |
Oxoglutaric acid; L-Arginine; L- Glutamine; N-Acetyl-L-aspartic acid; Citrulline |
35 | 5 | 0.00609 | 0.555 | 0.0747 |
| Glucose-alanine cycle |
L-Alanine; Oxoglutaric acid; Pyruvic acid |
13 | 3 | 0.00896 | 0.807 | 0.0976 |
|
Phenylalanine and tyrosine Metabolism |
L-Tyrosine; Phenylpyruvic acid; 4-Hydroxyphenylpyruvic acid; Oxoglutaric acid |
28 | 4 | 0.0144 | 1 | 0.141 |
| Carnitine synthesis |
Glycine; Oxoglutaric acid; Succinic acid |
22 | 3 | 0.0388 | 1 | 0.346 |
Pathway associated metabolite sets with p value < 0.05 are shown in the table