Table 3.
The significantly altered pathways between TAC and sham rats
| Pathway | Metabolites | P value |
|---|---|---|
| Lysine degradation | 5-Aminopentanoic acid, N6-acetyl-l-lysine, l-lysine | 0.0002 |
| Pyrimidine metabolism | Thymidine, pseudouridine,5-Methylcytosine, thymine | 0.0005 |
| Choline metabolism in cancer | PC(16:0/16:0), SOPC | 0.0019 |
| Protein digestion and absorption | l-Phenylalanine, l-Lysine, l-Histidine | 0.0027 |
| Aminoacyl-tRNA biosynthesis | l-Phenylalanine, l-lysine, l-histidine | 0.0037 |
| Retrograde endocannabinoid signaling | PC(16:0/16:0), SOPC | 0.0058 |
| Arginine and proline metabolism | 5-Aminopentanoic acid, 4-Guanidinobutyric acid, D-proline | 0.0115 |
| Linoleic acid metabolism | PC(16:0/16:0), SOPC | 0.0125 |
| Central carbon metabolism in cancer | l-Phenylalanine, l-histidine | 0.0214 |
| alpha-Linolenic acid metabolism | PC(16:0/16:0), SOPC | 0.0296 |
| Glycerophospholipid metabolism | PC(16:0/16:0), SOPC | 0.0403 |
SOPC: 1-stearoyl-2-oleoyl-sn-glycerol 3-phosphocholine