Table 3.

Single-cell human islet transcriptomic analysis showing gene expression profiles of GHSR, PPY, SST, and GHRL in 14 different identified cell clusters

Cluster ID	No. and (%) of total cells	No. and (%) of cells within each cluster expressing the following transcripts:
		PPY	SST	GHSR	PPY + GHSR	SST + GHSR	PPY + SST + GHSR	PPY + SST	GHRL	GHRL + GHSR
Alpha 1	3472 (24.8)	1509 (43.5)	2704 (77.9)	6 (0.2)	5 (0.1)	5 (0.1)	4 (0.1)	1314 (37.9)	139 (4.0)	2 (0.06)
Alpha 2	878 (6.3)	250 (28.5)	536 (61.1)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	197 (22.4)	19 (2.2)	0 (0.0)
Beta 1	3197 (22.8)	1139 (35.6)	2602 (81.4)	45 (1.4)	24 (0.8)	33 (1.0)	18 (0.6)	1069 (33.4)	98 (3.1)	1 (0.0)
Beta 2	301 (2.2)	109 (36.2)	251 (83.4)	3 (1.0)	1 (0.3)	3 (1.0)	1 (0.3)	107 (35.6)	8 (2.7)	0 (0.0)
Delta	954 (6.8)	386 (40.5)	944 (99.0)	211 (22.1)	126 (13.2)	211 (22.1)	126 (13.2)	385 (40.4)	28 (2.9)	6 (0.6)
Gamma	607 (4.3)	604 (99.5)	515 (84.8)	3 (0.5)	3 (0.5)	3 (0.5)	3 (0.5)	513 (84.5)	42 (6.9)	0 (0.0)
Epsilon	29 (0.2)	18 (62.1)	24 (82.8)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	16 (55.2)	29 (100.0)	0 (0.0)
Acinar	1696 (12.1)	479 (28.2)	1071 (63.2)	5 (0.3)	4 (0.2)	4 (0.2)	4 (0.2)	403 (23.8)	37 (2.2)	1 (0.06)
Ductal 1	1524 (10.9)	489 (32.1)	1127 (74.0)	1 (0.07)	1 (0.07)	1 (0.07)	1 (0.07)	420 (27.6)	28 (1.8)	0 (0.0)
Ductal 2	155 (1.1)	56 (36.1)	120 (77.4)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	47 (30.2)	3 (1.9)	0 (0.0)
Endothelial	337 (2.4)	84 (24.9)	262 (77.7)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	78 (23.2)	12 (3.6)	0 (0.0)
Macrophage	90 (0.6)	30 (33.3)	76 (84.4)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	30 (33.3)	3 (3.3)	0 (0.0)
Mast	45 (0.3)	18 (40.0)	37 (82.2)	1 (2.2)	0 (0.0)	1 (2.2)	0 (0.0)	15 (33.3)	0 (0.0)	0 (0.0)
Stellate	726 (5.2)	209 (28.8)	550 (75.8)	1 (0.1)	0 (0.0)	0 (0.0)	0 (0.0)	195 (26.9)	16 (2.2)	0 (0.0)

Abbreviations: ID, identification; PPY, pancreatic polypeptide; SST, somatostatin.