Table 5.

CYPs expressed in TNBC

CYPs	Log2 fold change	Function
4F8	8.5	Catalyzes hydroxylation of arachidonic acid, omega-2 and omega-3, PGH1 and PGH2, docosapentaenoic acid, PGI2, and epoxidation of docosahexaenoic acid and docosapentaenoic acid.
4F11	3.2	Catalyzes ω-hydroxylation of 1) short chain and medium chain to initiate β-oxidation and fatty acids and 2) leukotrienes and HETEs to initiate their inactivation.
4F22	11	The fatty acid ω-hydroxylase required for acylceramide synthesis. Its substrate is ultra–long-chain fatty acids.
27B1	16	Vitamin D 1-α hydroxylase.
4Z1	36	Catalyzes the production of 20-HETE from arachidonic acid, which stimulates growth and invasiveness of breast cancer cells.
26A1	6.5	Metabolizes and inactivates retinoic acid, terminating its prodifferentiative functions.
24A1	6.7	A 24-hydroxylase which inactivates calcitriol.
2J2	7.2	Catalyzes the conversion of endogenous polyunsaturated fatty acids to signaling molecules such as eicosatrienoic acid epoxides, which cause growth and invasiveness of MDA231 cells.