Table 3.
Univariate and multivariate analyses of clinical factors associated with successful weaning
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Age | 1.006 (0.963–1.052) | 0.783 | – | – |
| Sex (reference, female) | 2.708 (0.667–10.993) | 0.163 | 1.274 (0.154–10.527) | 0.822 |
| Smoking history (reference, yes) | 0.267 (0.084–0.847) | 0.025* | 0.544 (0.087–3.396) | 0.515 |
| Days on NIV until weaning, days | 0.716 (0.539–0.949) | 0.020* | 0.825 (0.562–1.211) | 0.326 |
| Albumin, g/dL | 2.561 (0.869–7.550) | 0.088 | 2.196 (0.555–8.694) | 0.262 |
| Systemic corticosteroids (reference, yes) | 1.736 (0.481–6.261) | 0.399 | – | – |
| Antibiotics (reference, yes) | 0.376 (0.104–1.358) | 0.135 | 0.405 (0.082–1.999) | 0.267 |
| COPD group (reference, C + D group) | 2.465 (0.811–7.487) | 0.112 | 1.556 (0.420–5.769) | 0.508 |
| Off NIV RSBI, breaths/(min∙mL) | 0.970 (0.956–0.984) | < 0.001* | 0.976 (0.959–0.993) | 0.006* |
| Off NIV MIP, −cmH2O | 1.026 (1.001–1.052) | 0.040* | – | – |
| Off NIV MEP; +cmH2O | 1.025 (1.003–1.048) | 0.026* | 0.996 (0.968–1.023) | 0.755 |
Obtained through enter model construction, including only significant independent predictors; OR of NIV treatment success associated with each variable in the model
CI confidence interval; COPD chronic obstructive pulmonary disease; MEP maximal expiratory pressure; MIP maximal inspiratory pressure; NIV noninvasive ventilation; OR odds ratio; RSBI rapid shallow breathing index
*P < 0.05, significant