Table 3.

Mann–Whitney Unpaired Tests and Kruskal–Wallis Analysis of Variance for All Nonreticular Pseudodrusen Participants with AREDS Step Grading at Baseline on Standard 5° Testing Protocol (82% Focal Bleach, Test Spot at 5°) Comparing Participants Who Had No Change, Decreased, or Increased AREDS Step at 4 Years

	Decrease or No Change in AREDS Step	Increase in AREDS Step (1 Step)	Increase in AREDS Step (≥2 Steps)	Transitioned to SDD
No.	37	15	7	5
Median slope† (IQR), min/yr	0.28 (0.07–1.2)	0.69 (0.16–1.8)	0.62 (0.29–1.4)	2.7 (2.2–3.7)
Mean slope† (SD), min/yr	0.60 (0.71)	1.0 (1.2)	0.85 (0.55)	2.9 (0.80)
Mann–Whitney P value‡		0.24	0.17	<0.0001*
	<0.0001§
Kruskal–Wallis analysis of variance P value	0.27∥		0.0027*,¶

AREDS = Age-Related Eye Disease Study; IQR = interquartile range; RIT = rod intercept time; SD = standard deviation; SDD = subretinal drusenoid deposits.

^*Statistically significant at P value < 0.05.

^†Slope RIT = linear regression of RIT values (minimum 5 data points).

^‡Compared with control group defined as eyes with a decrease or no change in AREDS step.

^§Eyes that do not transition to SDD (decrease or no change in AREDS step + increase in AREDS step [1 step] + increase in AREDS step [≥2 steps]) compared with eyes with transition to SDD.

^∥Comparing decrease or no change in AREDS step versus increase in AREDS step (1 step) versus increase in AREDS step (≥ 2 steps).

^¶Comparing decrease or no change in AREDS step versus increase in AREDS step (1 step) versus increase in AREDS step (≥ 2 steps) versus transition to SDD.