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. 2021 Aug 17;13:817–857. doi: 10.2147/JEP.S236743

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© 2021 Zolty.

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RhoA/Rho-kinase signaling pathway. Wthin PAEcs and PASMCs, Rho-Rho kinase can be activated by several pathological mediators, including angiotensin II (Ang II), endothelin-1 (ET-1) and 5-hydroxytryptamine (5-HT). Rho-Rho kinase activation leads to inhibition of myosin light chain phosphatase (MLCPh) and subsequently vasoconstriction. Rho-Rho kinase also contributes to endothelial dysfunction through negative regulation of endothelial nitric oxide synthase (eNOS) and phosphatidylinositol 3-kinase (PI3K) activity causing reduced NO bioavailability.

Abbreviations: ↓, decrease in; 5-HT, 5-hydroxytryptamine; Ang II, angiotensin II; ET-1, endothelin-1; eNOS, endothelial nitric oxide synthase; MLCPh, myosin light-chain phosphatase; NO, nitric oxide; PI3K, phosphatidylinositol 3-kinase.