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PCSK9 46L LOF individuals present heart failure with preserved ejection fraction. (A and B) Left ventricular mass index (g/m2) (P = 0.01) and ejection fraction (P = 0.10) of PCSK9 R46 and 46L carriers are shown. (C) Leg and arm skeletal muscle mass (quantified by Dual X-Rays Absorbimetry, following Hansen’s formula) (P = 0.26) is shown (R46, n = 516; 46L, n = 12). Non-parametric t-test was used to compare each group. (*P < 0.05).
