Table 2.

Drugs and type of cell death.

Drug	Model of study	ROS/antioxidant	Cell death type	Ref.
Methylprednisolone	Thymocytes0	Peroxides and decreased GSH	Apoptosis	[71]
Artesunate	Doxorubicin-resistant T leukemia cells	Hydrogen peroxide	Intrinsic apoptosis	[65]
Vibrio vulnificus cytolysin	Vascular endothelial ECV304 cells	Superoxide anion	Intrinsic apoptosis	[66]
Angiotensin II	Myocardial ischemia	Superoxide anion and/or hydrogen peroxide	Intrinsic apoptosis	[69]
TNF-α	Mesangial cells	Superoxide anion	Extrinsic apoptosis	[65]
Matrine	Liver HL-7702 cells	Hydrogen peroxide and lipid peroxidation Decreased SOD and GSH activity, KEAP1 upregulation, Nrf2 downregulation and inhibition of HO-1 and NQO1	Intrinsic and extrinsic apoptosis	[64]
Oxidized perilla and linseed oil	Neuronal SH-SY5Y cells	Hydrogen peroxide	Caspase-independent apoptosis (AIF) and intrinsic apoptosis	[74]
Clemastine and ibrutinib combination	CLL cells	Superoxide anion and/or hydrogen peroxide	Apoptosis	[72]
Sodium selenite	Prostate cancer PC3	Superoxide anion	Apoptosis	[115]
Glucose-decorated selenium nanoparticles	Hepatocellular carcinoma HepG2 cells	Superoxide anion and/or hydrogen peroxide	Apoptosis	[122]
BAY 87-2243	Hepatoma cell line Hep3B	ROS	Apoptosis	[137]
Siramesine and lapatinib combination	Breast cancer MDA MB 231cells, adenocarcinoma A549 cells, and glioblastoma U87 cells	Iron-mediated ROS and lipid peroxidation	Ferroptosis	[120, 121]
Paraquat and maneb	Neuronal SH-SY5Y cells	Lipid peroxidation NADPH-mediated ROS Decreased GSH and GPx4	Ferroptosis	[86]
Hemin	Monocytic THP-1 cells	Iron-mediated ROS and NADPH-mediated ROS	Ferroptosis	[85]
Artesunate	Hepatic stellate LX2 cells	Iron mediate ROS and lipid peroxidation Decreased GSH and GPx4 activity	Ferroptosis	[87]
Deletion of Acsl4 and RSL3	Acute kidney failure	Oxidation of fatty acids	Ferroptosis	[132]
Deletion of Acsl4 and TNF-α and zVAD-fmk	Acute kidney failure	Oxidation of fatty acids	Necroptosis	[132]
Rotenone	HEK 293, U87, and HeLa cells	Superoxide anion and/or hydrogen peroxide	Autophagic cell death	[99]
Bufaline	Colon cancer HT-29 and Caco-2 cells	Hydrogen peroxide	Autophagic cell death	[100]
Amyloid-β1-42	Glioblastoma U87 and SH-SY5Y cells	Hydrogen peroxide	Autophagic cell death	[101]
β-Lapachone	Glioblastoma U87 cells	Hydrogen peroxide	Autophagic cell death	[102]
Selenium nanoparticles	Prostate cancer PC3 cells	Superoxide anion and/or hydrogen peroxide	Necroptosis	[114]
Alkynyl gold(I) complex	Colorectal adenocarcinoma Caco-2 cells	ROS	Necroptosis	[116]
TNF-α	Mouse embryonic fibroblast RelA KO and cIAP1/2 DKO cells	Hydrogen peroxide	Necroptosis	[117]
FTY720	U87 and U251MG xenograft mouse model	ROS	Autophagy and ferroptosis and necroptosis	[118]
BAY 87-2243	BRAF mutant melanoma mouse xenografts and patient-derived melanoma mouse models	ROS and lipid peroxidation	Ferroptosis and necroptosis	[135]