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. 2021 Aug 13;2021:1394486. doi: 10.1155/2021/1394486

Figure 6.

Figure 6

Nrf2 knockdown affects the protective effect of MitoQ on Ang II-induced mitochondrial fission. (a) Western blot analysis of Nrf2 in podocytes transfected with Nrf2 siRNA or siRNA scrambles, n = 3. (b) Representative confocal microscopy image of MitoTracker Red staining in podocytes from each group (original magnification, ×1000), scale bar = 15 μm, n = 4. (c) Quantitative analysis of the mitochondrial aspect ratio from (b). (d) Western blot analysis of Opa1, Mfn2, Drp1, and Fis1 in podocytes from different groups, n = 3. (e) Quantitative analysis of protein levels from (d). ∗P < 0.05 vs. control; #P < 0.05 vs. Ang II; $P < 0.05 vs. Ang II+MitoQ 100 nM.