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. 2021 Aug 17;12:755–768. doi: 10.2147/JBM.S266791

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© 2021 Colonne et al.

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A simplified algorithm that describes the VWD diagnostic process using laboratory testing. This considers the differential utility of different VWF methods, as well as VWF multimers, and potentially genetic testing.

Abbreviations: Ag, antigen; CB, collagen binding; FVIII, factor VIIII; GPIb, glycoprotein Ib (the platelet VWF receptor); GPIbM, GPIb mutation-based assay; GPIbR, recombinant GPIb-based assay; HMW, high molecular weight (VWF); RCo, ristocetin cofactor; RIPA, ristocetin induced platelet aggregation; VWF, von Willebrand factor; VWD, von Willebrand disease.