Table 3.

Laboratory Work Up of a Patient with Suspected VWD

Investigation	Purpose
FBC + blood film	Platelet deficiencies Morphological changes
PT/APTT/fibrinogen	Screen of factor deficiencies
Blood group	To check for group O
FVIII VWF:Ag VWF:RCo or VWF:GPIbR (or VWF:GPIbM) VWF:CB	Initial screen for VWD
DDAVP Challenge VWF:FVIIIB Platelet aggregometry - RIPA Multimer assays	Extended testing for VWD: Type 1C VWD, Type 2N VWD 2A vs 2B vs PT-VWD
Genetic studies	Confirmatory testing: Type 2A, 2B, 2M, 2N, PT-VWD, Type 3 VWD
1-hour and 4-hour desmopressin trial	Type 1C VWD