Fig. 3.

Alteration in sex-specific hepatic lipid metabolism during cell culture. a, b Activation Z-score analysis of the RNA array and proteome analyses related to lipid metabolism. Colors show the activation Z-score of male compared to female hepatocytes. Activation Z-score was calculated using IPA software with a p value cut-off of 0.05. Crossed squares mark non-significant values. c–e Extracellular metabolome analysis. Error bars show SEM. Significance was calculated with two-way-ANOVA. Stars show the significance between hepatocytes from male and female mice at a certain time point. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. N = 5