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. 2021 Jul 9;95(9):3001–3013. doi: 10.1007/s00204-021-03118-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Sex-specific amino acid (AA) consumption of hepatocytes. a Activation Z-score analysis of the RNA array of genes related to AA degradation. Colors show the activation Z-score of male compared to female hepatocytes. Activation Z-score was calculated using IPA software with a p value cut-off of 0.05. b-m Extracellular metabolome analysis. Error bars show SEM. Significance was calculated with two-way ANOVA. Stars show the significance between female and male mouse hepatocytes. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. N = 5