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. 2021 Jul 17;95(9):3049–3062. doi: 10.1007/s00204-021-03114-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — UpSet plot depicting the number and intersections of the features with VIP > 1 in the hepatocellular DILI vs. the group of cholestatic DILI and recovered patients, cholestatic DILI vs. the group of hepatocellular DILI and recovered patients, and recovered vs. the group of hepatocellular and cholestatic DILI patients PLS–DA models. Pie plots show the distributions of the main subclasses of the features selected as discriminant in the three models. Note: NA: features with no subclass included in the HMDB