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. 2021 Aug 21;7:218. doi: 10.1038/s41420-021-00604-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Heatmap of microarray analysis showing the up- and downregulated circRNAs in three pairs of cancer tissue and normal tissue. B RT-PCR demonstrated several upregulated circRNAs in TNBC specimens, including circPDCD11. C Schematic diagram showing that circPDCD11 was derived from PDCD11 pre-mRNA and generated through exon 27 ~ exon 24 back splicing (hsa_circ_0019853, 461 bp). D RT-PCR demonstrated circPDCD11 and linear transcript (PDCD11 mRNA) expression after treatment with RNase and actinomycin D. E RT-PCR demonstrated circPDCD11 expression in TNBC clinical specimens (32 samples) compared with adjacent normal specimens (32 samples). F Kaplan–Meier survival analysis illustrated the correlations between circPDCD11 expression (high = 16, low = 16) and overall survival of the TNBC patients from the enrolled samples. A p value was calculated using a log-rank test. Data are expressed as the mean ± SD. **p < 0.01.