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. 2021 Aug 21;7:218. doi: 10.1038/s41420-021-00604-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A RT-qPCR demonstrated circPDCD11 expression as measured in TNBC cell lines (BT549, MDA-MB-468, and MDA-MB-231) and human normal breast cells (MCF10A). B Lentivirus-mediated small-hairpin RNA (shRNA) and plasmid transfection were performed to effectively downregulate (MDA-MB-468) or upregulate (BT549) the endogenous expression of circPDCD11. C Glucose uptake was assessed using the Glucose Uptake Colorimetric Assay Kit. D Lactate-production analysis was quantified using a Lactate Colorimetric Assay Kit. E ATP quantity was quantified using the CellTiter-Glo Luminescent Cell Viability Assay Kit. F The extracellular acidification rate (ECAR) was quantified using a Bioscience XF96 Extracellular Flux Analyzer. The data are presented as the mean ± SD. Asterisks indicate significant differences (**p < 0.01, *p < 0.05).