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. 2021 Aug 21;7:218. doi: 10.1038/s41420-021-00604-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Online bioinformatics predictive tools identified the potential targets of circPDCD11/miR-432-5p. B The multiple complementary binding sites within miR-432-5p and LDHA, including wild type and mutant. C The luciferase reporter assay demonstrated the close interaction between wild-type LDHA mRNA 3′-UTR and miR-432-5p. The fluorescence intensity was assessed. D Western blot analysis assessed the LDHA protein level in BT549 cells transfected with circPDCD11 overexpression and/or cotransfected with miR-432-5p mimics. E Clinical correlation analysis calculated by Pearson’s correlation showed the correlation between circPDCD11 and LDHA. The data are presented as the means ± SD. Asterisks indicate significant differences (**p < 0.01).