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. 2021 Aug 21;12(9):803. doi: 10.1038/s41419-021-04089-6

Fig. 8. Co-treatment of IU1 and USP14 knockdown suppresses HCC cell growth in mice.

Fig. 8

A–C BALB/c nude mice, at two weeks after inoculation with HCCLM3 cells stably expressing either human USP14-specific shRNA or control shRNA, were administrated orally with IU1 (40 mg/kg, every two days) for 14 days. Xenograft images (A), tumor volume (B), and tumor weight (C) were presented. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; ns = no significance. D Representative micrographs of immunohistochemistry staining for USP14, HIF1-α, and Ki67 in explanted tumor tissues. Scale bar, 100 μM. E The schematic diagram of USP14 promotes the procession of HCC by stabilizing HIF1-α and activating HIF1-α transcription via deubiquitination.