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. 2021 Aug 17;14:4001–4017. doi: 10.2147/JIR.S324232

Figure 1.

Figure 1

The role of ADA2AR on bone healing. (A) A schematic diagram. 45 rats were divided into 3 groups and were received fracture site injection after modeling. (B) HE staining and Goldner trichrome staining of the fracture site. CGS21680 promoted the new bone formation at 7 days (red region, arrows) and callus formation at 14, 28 days (arrows), while ZM241385 inhibited bone formation and caused serious inflammatory reaction at 14, 28 days (arrows). Images, ×25; original scale bar, 500 μm. (C) half-box graphs showed the difference between groups, *p<0.05. n=5 at each timepoint.