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. 2021 Aug 17;14:4001–4017. doi: 10.2147/JIR.S324232

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© 2021 Wang et al.

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The role of ADA2AR in macrophages regulating VECs in BFM. (A) ADA2AR activation or inhibition had no difference on VECs migration in macrophage-VEC coculture model. Inhibited macrophage-exosomes weakened the VECs migration. Transwell images, ×50; original scale bar, 100 μm. (B) Violin plots showed the cell migration results, *p<0.05. n=5. (C) Inhibited ADA2AR inhibited tube formation while activated ADA2AR had no significantly promote tube formation. Inhibited macrophage-exosomes inhibited the tube formation. The contrast and brightness were evenly adjusted for each picture. Images ×100; original scale bar, nonfluorescent images 100 μm; fluorescent images 50 μm. (D) Half-box graphs showed the vascular tube formation results, *p<0.05. n=5.