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. 2021 Aug 17;14:4001–4017. doi: 10.2147/JIR.S324232

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© 2021 Wang et al.

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The role of ADA2AR in macrophage-exosomes regulating VECs. (A) inhibited macrophage secreting exosomes decreased the VECs migration. Macrophages were treated with CGS21680 or CGS21680+10μM GW4869 and the supernatant of macrophages was used in the lower chamber in Transwell inserts (8-µm pore size). Transwell images, ×50; original scale bar, 200 μm. The violin plots showed the difference between groups, *p<0.05. n=5. (B) Inhibited macrophages-exosomes inhibited tube formation. Macrophages were treated with CGS21680, ZM241385, DMSO or CGS21680+GW4869 and the supernatant of macrophages was used. The contrast and brightness were evenly adjusted for each picture. Images ×100; original scale bar, nonfluorescent images 100 μm; fluorescent images 50 μm. (C) Half-box graphs showed the difference between groups, *p<0.05. n=5.