Table 3.
Multivariate analysis of covariates for survival in breast cancer
| Covariates | HR | 95% CI | P |
|---|---|---|---|
| TCGA | |||
| GAM status (ref: GAM-Low) | 0.16 | 0.07–0.37 | < 0.001 |
| Age (ref: <= 50) | 2.19 | 1.11–4.35 | 0.023 |
| Pathological stage (ref: stage I) | 2.79 | 0.86–6.05 | 0.09 |
| Histologic type (ref: IDC) | 0.52 | 1.11–4.35 | 0.13 |
| PAM50 (ref: normal) | |||
| Luminal A | 0.51 | 0.10–2.56 | 0.41 |
| Luminal B | 0.74 | 0.15–3.71 | 0.71 |
| Basal | 0.28 | 0.05–1.39 | 0.11 |
| Her2 | 0.47 | 0.07–3.06 | 0.42 |
| GSE75067 | |||
| GAM status (ref: GAM-Low) | 0.39 | 0.21–0.74 | 0.003 |
| Age (ref: <= 50) | 2.03 | 1.25–3.30 | 0.004 |
| Histologic type (ref: IDC) | 0.61 | 0.29–1.26 | 0.18 |
| PAM50 (ref: normal) | |||
| Luminal A | 1.99 | 0.43–9.27 | 0.37 |
| Luminal B | 4.73 | 1.07–20.96 | 0.04 |
| Basal | 4.64 | 1.05–20.59 | 0.04 |
| Her2 | 7.75 | 1.77–34.1 | 0.006 |
HR hazard ratio, CI confidence interval, GAM gene associated methylation, IDC invasive ductal carcinoma