TABLE 2.
Effect of treatment‐related factors: cell type
| Cell type | No. of articles | WMD/SMD [95% CI] | Comparison group | P value |
|---|---|---|---|---|
| Creatinine (mg/dL) | ||||
| MSC | 13 | −0.29 [−0.36, −0.22] | MSC vs UC/AF | .7 |
| UC/AF | 4 | −0.34 [−0.57, −0.10] | MSC vs Non‐MSC | <.0001 |
| Non‐MSC | 1 | −0.10 [−0.13, −0.07] | MSC vs Product | .7 |
| Cell product | 2 | −0.41 [−1.03, 0.20] | Non‐MSC vs UC/AF | .05 |
| — | Non‐MSC vs Product | .3 | ||
| — | UC/AF vs Product | .8 | ||
| — | Non‐MSC vs Product | .09 | ||
| Urea (mg/dL) | ||||
| MSC | 12 | −31.66 [−44.46, −18.85] | MSC vs UC/AF | .06 |
| UC/AF | 3 | −17.32 [−25.22, −9.42] | MSC vs Non‐MSC | .08 |
| Non‐MSC | 1 | −19.25 [−24.33, −14.17] | MSC vs Product | .3 |
| Cell product | 2 | −59.22 [−105.86, −12.59] | UC/AF vs Non‐MSC | .7 |
| — | UC/AF vs Product | .08 | ||
| — | Non‐MSC vs Product | .09 | ||
| Urine protein | ||||
| MSC | 20 | −2.38 [−2.97, −1.79] | MSC vs UC/AF | .03 |
| UC/AF | 3 | −26.43 [−48.19, −4.67] | MSC vs Non‐MSC | .3 |
| Non‐MSC | 2 | −43.85 [−116.81, 29.10] | MSC vs Product | .2 |
| Cell product | 4 | −3.823 [−5.68, −1.96] | UC/AF vs Non‐MSC | .7 |
| — | UC/AF vs Product | .04 | ||
| — | Non‐MSC vs Product | .3 | ||
| Fibrosis | ||||
| Pro‐fibrosis | ||||
| MSC | 16 | −3.93 [−5.03, −2.83] | MSC vs UC/AF | .5 |
| UC/AF | 2 | −2.50 [−6.68, 1.68] | MSC vs Non‐MSC | .4 |
| Non‐MSC | 3 | −5.30 [−8.28, −2.32] | MSC vs Product | .03 |
| Cell product | 2 | −9.51 [−14.28, −4.73] | Non‐MSC vs UC/AF | .3 |
| — | Non‐MSC vs Product | .1 | ||
| — | UC/AF vs Product | .03 | ||
| Antifibrosis | ||||
| MSC | 3 | 4.01 [0.87, 7.15] | MSC vs UC/AF | .1 |
| UC/AF | 1 | 1.33 [0.15, 2.50] | — | — |
| Inflammation | ||||
| Blood pro‐inflammation | ||||
| MSC | 5 | −2.83 [−3.71, −1.95] | MSC vs UC/AF | .7 |
| UC/AF | 1 | −3.62 [−7.07, −0.18] | — | — |
| Blood anti‐inflammation | — | |||
| MSC | 2 | 0.99 [0.33, 1.64] | — | — |
| Kidney pro‐inflammation | — | |||
| MSC | 9 | −3.27 [−4.80, −1.74] | — | — |
| UC/AF | — | MSC vs Non‐MSC | .05 | |
| Non‐MSC | 1 | −1.22 [−2.60, 0.16] | — | — |
| Cell product | — | — | — | |
| Kidney anti‐inflammation | — | — | — | |
| MSC | 4 | 3.71 [1.65, 5.76] | — | — |
| — | — | — | ||
Note: Bold values are those that are statistically significant.
Abbreviations: CI, confidence interval; MSC, mesenchymal stem cells; Non‐MSC, other cells; SMD, standardized mean difference; UC/AF, umbilical cord/amniotic fluid cells; UCB, umbilical cord and amniotic fluid stem cells; WMD, weighted mean difference.