TABLE 3.

Effect of treatment‐related factors: cell tissue source

Cell tissue source	No. of articles	WMD/SMD [95% CI]	Comparison group	P value
Creatinine (mg/dL)
BM	9	−0.39 [−0.47, −0.30]	BM vs Adipose	<.0001
Adipose	3	−0.14 [−0.20, −0.09]	BM vs UC/AF	.7
UC/AF	6	−0.35 [−0.56, −0.13]	BM vs Other	<.0001
Other	2	−0.07 [−0.21, 0.07]	UC/AF vs Adipose	.07
		—	UC/AF vs Other	.04
		—	Adipose vs Other	.4
Urea (mg/dL)
BM	9	−30.99 [−46.17, −15.81]	BM vs Adipose	.01
Adipose	3	−9.87 [−15.57, −4.18]	BM vs UC/AF	.2
UC/AF	4	−44.16 [−57.08, −31.24]	BM vs Other	.2
Other	2	−19.72 [−24.73, −14.70]	Adipose vs UC/AF	<.0001
		—	Adipose vs Other	.01
		—	Other vs UC/AF	.0005
Urine protein
BM	20	−2.54 [−3.135, −1.945]	BM vs UC/ AF	.03
UC/AF	4	−8.32 [−13.57, −3.07]	BM vs Other	.06
Other	4	−6.22 [−10.02, −2.42]	UC/AF vs Other	.5
Fibrosis
Pro‐fibrosis
BM	15	−4.34 [−5.56, −3.12]	BM vs Adipose	.2
Adipose	2	−2.86 [−4.64, −1.08]	BM vs UC/AF	1.0
UC/AF	4	−4.37 [−7.64, −1.09]	BM vs Other	.03
Other	2	−9.61 [−14.32, −4.89]	UC/AF vs Adipose	.4
		—	UC/AF vs Other	.07
		—	Adipose vs Other	.009
Antifibrosis
BM	2	6.84 [−4.02, 17.69]	BM vs UC/AF	.3
UC/AF	2	1.32 [0.49, 2.15]	—	—
Inflammation
Blood pro‐inflammation
BM	3	−2.46 [−3.36, −1.55]	BM vs Adipose	.4
Adipose	2	−3.43 [−5.53, −1.33]	BM vs UC/AF	.5
UC/AF	1	−3.62 [−7.07, −0.18]	Adipose vs UC/AF	.9
Blood anti‐inflammation
BM	2	0.99 [0.33, 1.64]	—	—
Kidney pro‐inflammation
BM	8	−3.33 [−5.03, −1.64]	BM vs Adipose	.9
Adipose	1	−3.12 [−4.64, −1.61]	BM vs Kidney	.06
Kidney	1	−1.22 [−2.60, 0.16]	Adipose vs Kidney	.07
Kidney anti‐inflammation
BM	4	3.71 [1.65, 5.76]	—	—

Note: Bold values are those that are statistically significant.

Abbreviations: BM, bone marrow; CI, confidence interval; SMD, standardized mean difference; UC/AF, umbilical cord/amniotic fluid; WMD, weighted mean difference.